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Student Competition I

Student Competition I

Session: Student Competition I

34 - Effects of Elevated Ambient Temperature on Response of a Mosquito Citronellal Receptor: Implications for the Efficacy of Mosquito Repellents

Tuesday, March 5, 2024
1:55pm – 2:05pm  
Location: A1
Abstract: I explored the impact of noxious heat on the chemical activation of transient receptor potential ankyrin 1 (TRPA1) in mosquitoes. TRPA1 is a receptor of noxious heat and repellents, but whether heat modulates TRPA1 response to repellents is unknown. By using whole-cell voltage clamping of heterologously expressed Aedes aegypti TRPA1, I found that heat reduced its activation by citronellal. My findings suggest the possibility of reduced efficacy of repellents targeting TRPA1 under extreme heat events.