Lesser Known Arboviruses Symposium I
Lesser Known Arboviruses Symposium I
Cache Valley virus (CVV) is a mosquito-borne virus in the genus Orthobunyavirus, family Peribunyaviridae. CVV is teratogenic in ruminants, causing fetal death and severe malformations during epizootics in the United States. CVV has caused severe human disease in seven individuals. Limited information exists on CVV regarding its geographic distribution, ecological cycle, seroprevalence in humans and animals, and spectrum of disease, including potential as a human teratogen. This presentation will outline the current knowledge regarding CVV’s virological characteristics, ecology, and clinical disease in ruminants and humans. Current diagnostic techniques available and newly developed reagents for serological detection, including an IgM antibody capture ELISA (MAC-ELISA) with engineered human IgM positive control, will also be discussed. Lastly, the presentation will highlight past and current seroprevalence studies in the United States, Canada, and Mexico and emphasize gaps in current knowledge and considerations for future research.