141 - Genetic structure and kdr mutations in Aedes aegypti populations along a road crossing the Amazon Forest in Amapá State, Brazil

In the state of Amapá, Brazil, insecticide resistance in Aedes aegypti, driven by kdr mutations in the Na_V gene, was investigated in six isolated locations in the Amazon Rainforest. Using microsatellite markers and qPCR, we identified three prevalent KDR mutations and two distinct genetic clusters, with Oiapoque showing greater genetic differentiation and frequency of kdr mutations. These findings emphasize the importance of passive dispersal and the need for surveillance to combat resistance in Ae. aegypti.